Research
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Our Fermented Wheat Germ Extract is very rich in Polyamines. The three principal Polyamines are Spermidine, Spermine, and Putrescine. The beneficial natural process that they induce in our bodies is called Autophagy.
There has been significant research on these compounds and topics, supporting a wide range of benefits.
Below, please find a selection of scientific studies and research articles* for your education.
Anti-Aging
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Spermidine delays aging in humans
Spermidine surprise for a long life
Spermidine: a novel autophagy inducer and longevity elixir
Higher spermidine intake is linked to lower mortality
Induction of autophagy by spermidine promotes longevity
Spermidine in health and disease
Should we skip a meal every day or indulge in a spermidine rich diet?
Molecular basis of the anti-aging effect of spermidine and other natural polyamines
Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro
Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity
Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine‑rich diet
A metabolic profile of polyamines in parkinson disease - a promising biomarker
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
Biological effects of polyamines on the prevention of aging-associated diseases
Can autophagy promote longevity?
Circadian clock control by polyamine levels through a mechanism that declines with age
Decrease in polyamines with aging and their ingestion from food and drink
Dietary and gut microbiota polyamines in obesity- and age-related diseases
Fermented Wheat Germ Extract inhibits adjuvant arthritis
Polyamine-rich food decreases age-associated pathology and mortality in aged mice
Polyamines and aging - a clear connection?
Polyamines in aging and disease
Remaining mysteries of molecular biology - the role of polyamines in the cell
Spermidine and spermine are enriched in whole blood of nona/centenarians
The curious case of polyamines: spermidine drives reversal of B cell senescence
Caloric Restriction Mimetics against age-associated disease - targets, mechanisms, and therapeutic potential
Anti aging treatments slow propagation of synucleinopathy by restoring lysosomal function
Autophagy renovation of cells and tissues
Development of autophagy inducers in clinical medicine
Guidelines for the use and interpretation of assays for monitoring autophagy
Hallmarks of aging: an autophagic perspective
Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen
Transcriptional and epigenetic regulation of autophagy in aging
Cancer Protection
Spermidine reduces cancer-related mortality in humans
Spermidine as a target for cancer therapy
A Study of the Role of Spermidine/Spermine N1-Acetyltransferase (SSAT) in Polyamine Homeostasis in Human Prostate Cancer Cells
Dietary polyamine intake and colorectal cancer risk in postmenopausal women
Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy
Fermented Wheat Germ Extract - nutritional supplement or anticancer drug
Fermented Wheat Germ Extract in the treatment of cancer and autoimmune diseases
The effects of adjuvant Fermented Wheat Germ Extract on cancer cell lines: a systematic review
A medical nutriment has supportive value in the treatment of colorectal cancer
A multicentric prospective open trial on the quality of life and oxidative stress in patients affected by advanced head and neck cancer
Adjuvant fermented wheat germ extract nutraceutical improves survival of high-risk skin melanoma patients
Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity
Fermented Wheat Germ Extract Inhibits T-cell Leukemia Tumor Cells
Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients
Recommendation of the Hungarian Society for Face, Mandible and Oral Surgery in the indication of supportive therapy
Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats
Autophagy in natural and therapy driven anticancer immunosurveillance
Autophagy induction for the treatment of cancer
Autophagy in malignant transformation and cancer progression
Cardiovascular Protection
Dietary spermidine for lowering high blood pressure
Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes
Cardioprotection and lifespan extension by the natural polyamine spermidine
Cardioprotective benefits of dietary spermidine
Revitalising the aged heart heart through a spermidine-rich diet
Spermidine promotes cardioprotective autophagy
Fermented Wheat Germ Extract in the treatment of cardiac remodeling and metabolic symptoms in rats
Spermidine to the rescue for an aging heart
Spermine and spermidine reversed age-related cardiac deterioration in rats
Spermine inhibits endoplasmic reticulum stress-induced apoptosis - a new strategy to prevent cardiomyocyte apoptosis
The autophagy enhancer spermidine reverses arterial aging
Neurological Protection
Spermidine boosts autophagy to protect from synapse aging
Spermidine protects against alpha synuclein neurotoxicity
Spermidine-triggered autophagy ameliorates memory during aging
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline
The effect of spermidine on memory performance in older adults at risk for dementia
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
Spermidine for a long dementia-free life
Spermidine in dementia
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Age-related changes in polyamines in memory-associated brain structures in rats
Polyamines in human brain - regional distribution and influence of aging
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
Synergistic Benefits
Spermidine coupled with exercise rescues skeletal muscle atrophy
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Bioavailability & Safety
Long-term oral polyamine intake increases blood polyamine concentrations
Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
Safety studies regarding a standardized Extract of Fermented Wheat Germ
Obesity & Metabolic Protection
Hair Growth
A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans
Spermidine promotes human hair growth and Is a novel modulator of human epithelial stem cell functions
*We take intellectual property rights very seriously. Kindly note that neither CellFend nor any of our affiliates nor subsidiaries were involved with the funding or publication of any of these studies or articles. As such, there are no conflicts that arise. All intellectual and property rights belong to either the respective author(s) or the journal. This product is neither associated with nor endorsed by any of the respective author(s) or the journals cited above. These studies and articles are cited in their original form under the Open Access policy of the Fair Use law. If you are an author or journal representative of one of the aforementioned studies or articles, and if you believe that any of the above publications have been posted in violation of copyright, please contact us. It is not our intent to violate anyone's intellectual property rights. Therefore, we will carefully evaluate any take-down requests we receive and advise of our findings. In the event our analysis determines there exists a potential violation of intellectual property rights, we will act on it immediately.