As part of our ongoing commitment to transparency, we strive to give you as much comfort as possible in our product, through brining you insight into both our production quality and supporting evidence. 

Our Fermented Wheat Germ Extract is very rich in Polyamines.  The three principal Polyamines are Spermidine, Spermine, and Putrescine.  The beneficial natural process that they induce in our bodies is called Autophagy.

There has been significant research on these compounds and topics, supporting a wide range of benefits. 

Below, please find a selection of scientific studies and research articles* for your education.  


Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Spermidine delays aging in humans

Spermidine surprise for a long life

Spermidine: a novel autophagy inducer and longevity elixir

Higher spermidine intake is linked to lower mortality

Induction of autophagy by spermidine promotes longevity

Spermidine in health and disease

Should we skip a meal every day or indulge in a spermidine rich diet?

Molecular basis of the anti-aging effect of spermidine and other natural polyamines

Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro

Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity

Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine‑rich diet

A metabolic profile of polyamines in parkinson disease - a promising biomarker

Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol

Biological effects of polyamines on the prevention of aging-associated diseases

Can autophagy promote longevity?

Circadian clock control by polyamine levels through a mechanism that declines with age

Decrease in polyamines with aging and their ingestion from food and drink

Dietary and gut microbiota polyamines in obesity- and age-related diseases

Fermented Wheat Germ Extract inhibits adjuvant arthritis

Polyamine-rich food decreases age-associated pathology and mortality in aged mice

Polyamines and aging - a clear connection?

Polyamines in aging and disease

Remaining mysteries of molecular biology - the role of polyamines in the cell

Spermidine and spermine are enriched in whole blood of nona/centenarians

The curious case of polyamines: spermidine drives reversal of B cell senescence 
Caloric Restriction Mimetics against age-associated disease - targets, mechanisms, and therapeutic potential

Anti aging treatments slow propagation of synucleinopathy by restoring lysosomal function

Autophagy renovation of cells and tissues

Development of autophagy inducers in clinical medicine

Guidelines for the use and interpretation of assays for monitoring autophagy

Hallmarks of aging: an autophagic perspective

Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen

Transcriptional and epigenetic regulation of autophagy in aging 

Cancer Protection

Spermidine reduces cancer-related mortality in humans
Spermidine as a target for cancer therapy 
A Study of the Role of Spermidine/Spermine N1-Acetyltransferase (SSAT) in Polyamine Homeostasis in Human Prostate Cancer Cells
Dietary polyamine intake and colorectal cancer risk in postmenopausal women
Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy
Fermented Wheat Germ Extract - nutritional supplement or anticancer drug
Fermented Wheat Germ Extract in the treatment of cancer and autoimmune diseases
The effects of adjuvant Fermented Wheat Germ Extract on cancer cell lines: a systematic review
A medical nutriment has supportive value in the treatment of colorectal cancer
A multicentric prospective open trial on the quality of life and oxidative stress in patients affected by advanced head and neck cancer
Adjuvant fermented wheat germ extract nutraceutical improves survival of high-risk skin melanoma patients
Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity
Fermented Wheat Germ Extract Inhibits T-cell Leukemia Tumor Cells
Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients
Recommendation of the Hungarian Society for Face, Mandible and Oral Surgery in the indication of supportive therapy
Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats
Autophagy in natural and therapy driven anticancer immunosurveillance
Autophagy induction for the treatment of cancer
Autophagy in malignant transformation and cancer progression

*We take intellectual property rights very seriously. Kindly note that neither CellFend nor any of our affiliates nor subsidiaries were involved with the funding or publication of any of these studies or articles. As such, there are no conflicts that arise. All intellectual and property rights belong to either the respective author(s) or the journal. This product is neither associated with nor endorsed by any of the respective author(s) or the journals cited above. These studies and articles are cited in their original form under the Open Access policy of the Fair Use law. If you are an author or journal representative of one of the aforementioned studies or articles, and if you believe that any of the above publications have been posted in violation of copyright, please contact us. It is not our intent to violate anyone's intellectual property rights. Therefore, we will carefully evaluate any take-down requests we receive and advise of our findings. In the event our analysis determines there exists a potential violation of intellectual property rights, we will act on it immediately.