Benefits
There are numerous benefits to autophagy induction:
Promotes Healthy Cellular Aging
Polyamines have been shown to suppress age-related decline of our cells and repair them into new and healthy cells.
("Polyamines in aging and disease", AGING, August 2011, Vol. 3 No. 8)
Cleans Out Damaged Cells
Dead, diseased, or worn-out cells are disassembled and recycled.
("Autophagy: Renovation of Cells and Tissues", Cell 147, Nov 2011)
Builds New Healthy Cells
The old damaged cells are recycled into new parts for healthy cells.
("Autophagy: Renovation of Cells and Tissues", Cell 147, Nov 2011)
Caloric Restriction Mimetic (CRM)
Caloric Restriction Mimetics (CRMs) pharmacologically mimic the beneficial effects of caloric restriction or fasting.
Polyamines have emerged as well-tolerated CRMs targeting various molecular and physiological age associated adversities.
In clinical trials, a strong argument in favor of Polyamines as a CRM is their low toxicity yet strong efficacy.
(“Caloric Restriction Mimetics against Age-Associated Disease: Targets,
Mechanisms, and Therapeutic Potential”, Cell Metabolism 29, March 5, 2019)
Scientific Research
There is well-documented research on Polyamines and their role in health and longevity.
View the Research
Neurological Protection
Polyamine supplementation has been shown to protect against age-induced memory impairment (AMI), brain aging, and synapse degradation.
("Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner", Nature Neuroscience, Sept 2013)
Cardiovascular Protection
Oral supplementation of Polyamines has been shown to have cardioprotective effects.
("Cardioprotection and lifespan extension by the natural polyamine spermidine", Nature Medicine Journal, Dec 2016)
Obesity & Metabolic Protection
Increased Polyamine levels have been linked to improving key cellular processes such as cellular metabolism, improved adaptability to stress, increased fitness, and resistance to obesity.
("Revitalising the aged heart through spermidine-rich diet", Health Management.org, Volume 19, Issue 2, 2019)
Benzoquinone Benefits
Fermented Wheat Germ Extract contains 2-methoxy benzoquinone and 2, 6-dimethoxy
benzoquinone, which are a type of organic compound known as quinones. These have been shown to play a significant role in promoting cellular health.
("Fermented Wheat Germ Extract Inhibits Glycolysis / Pentose Cycle Enzymes and Induces Apoptosis through Poly (ADP-ribose) Polymerase Activation in Jurkat T-cell Leukemia Tumor Cells", The Journal of Biological Chemistry, Vol. 277, No. 48, Nov 2002)
Cellular Senescence Reversal
Polyamines have been shown to reverse cellular senescence. Healthy cells continually divide to replace old and damaged tissue. However, as we age, some cells stop dividing, which is known as “cellular senescence”. These senescent cells damage the healthy cells around them, and this leads to a number of age-related diseases. Cellular senescence reversal is a critical component in healthy aging and cellular optimization.
(“ The curious case of polyamines: spermidine drives reversal of B cell senescence”, Autophagy, Volume 16, 2020 - Issue 3)
High Bioavailability
The long-term oral intake of enhanced Polyamine diets increases blood Polyamine levels, which means that Polyamines are well-absorbed and maintained by the body.
("Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations", Journal of Nutritional Science and Vitaminology, 55, 361-366, 2009)
Highly Synergistic
Combined with exercise, Polyamines have been shown to have an increased ability to mitigate aging-related skeletal muscle atrophy and have other beneficial impacts on a cellular level.
When Polyamines are taken in combination with Resveratrol, the autophagy induction levels have been shown to be higher than when Resveratrol is just taken alone.
("Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway", Oncotarget, 2017, Vol. 8, (No. 11), pp: 17475-17490 & "Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome", The Journal of Cell Biology, Vol. 192 No. 4 615–629)
Suppresses Cellular Inflammation
Polyamines have been shown to suppress oxidative and inflammatory effects on human cells. RNA sequencing analysis has shown that Polyamines suppress genes enriched in autoimmune diseases and inflammatory responses.
("Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity", iScience 23, Jan 2020)
Promotes Hair Growth
Polyamines have been shown to be potent stimulators of human hair growth, prolong the anagen (hair growth) phase, and be modulators of human epithelial stem cell (hair follicle) biology.
("Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions", Public Library of Science (PLOS) One Journal, Vol. 6, Issue 7, Jul 2011 & "A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles
in humans: a randomized, placebo controlled, double-blind study", Dermatology Practical & Conceptual Journal, 2017;7(4):5)
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