Research

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There are numerous, well-documented health benefits of the long pepper (scientifically known as 'piper longum') and piperlongumine.

Piperlongumine is a potent, all-natural senolytic agent, which is able to selectively target and kill senescent "zombie" cells.

Senolytic agents have shown interesting anti-aging bioactivities, which have led to great interest in their use by the pharmaceutical industry.

There has been significant research on these compounds and topics, supporting a wide range of benefits. 

Below, please find a selection of scientific studies and research articles* for your education.  

Long Pepper (Piper Longum)

A systematic review on Piper longum L. - Bridging traditional knowledge and pharmacological evidence for future translational research

Anticancer Principles from Medicinal Piper Plants

Antihyperlipidemic Compounds from the Fruit of Piper longum L.

Anti-inflammatory and antioxidant properties of Piper species - a perspective from screening to molecular mechanisms

Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L

Antiplatelet effects of acidamides isolated from the fruits of Piper longum L

Anti-stress and nootropic activity of aqueous extract of Piper longum fruit, estimated by noninvasive biomarkers and Y-maze test in rodents

Overview for Various Aspects of the Health Benefits of Piper Longum Linn. Fruit

Piper longum inhibits VEGF and proinflammatory cytokines and tumor-induced angiogenesis in C57BL6 mice

Piper Species - A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Protective effect of Piper longum fruit ethanolic extract on radiation induced damages in mice - A preliminary study

Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats

Recent studies on well-known spice, Piper longum Linn.

Review on potential antiviral and immunomodulatory properties of Piper Longum

Piperlongumine

Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis

Antiplatelet activities of newly synthesized derivatives of piperlongumine

Biological and physical approaches on the role of piplartine (piperlongumine) in cancer

Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents

Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury

Enhancement of piperlongumine chemosensitivity by silencing heme oxygenase-1 expression in cholangiocarcinoma cell lines

Horner-Wadsworth-Emmons approach to piperlongumine analogues with potent anti-cancer activity

Identification and optimization of piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2

Leishmanicidal Effects of Piperlongumine (Piplartine) and Its Putative Metabolites

Long lasting preventive effects of piperlongumine and a Piper longum extract against stress triggered pathologies in mice

Metabolic profile and safety of piperlongumine

Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells

Overview of piperlongumine analogues and their therapeutic potential

Overview of the therapeutic potential of piplartine (piperlongumine)

Piperlongumine (piplartine) and analogues - Antiproliferative microtubule-destabilising agents

Piperlongumine (piplartine) as a lead compound for anticancer agents - Synthesis and properties of analogues - A mini-review

Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished T H 17 but Enhanced T reg Differentiation

Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer

Piperlongumine as anticancer agent - The story so far about killing many birds with one stone

Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice

Piperlongumine increases sensitivity of colorectal cancer cells to radiation - Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems

Piperlongumine increases the apoptotic effect of doxorubicin and paclitaxel in a cervical cancer cell line

Piperlongumine induces apoptosis and autophagy in leukemic cells through targeting the PI3K - Akt - mTOR and p38 signaling pathways

Piperlongumine induces apoptosis and G 2M phase arrest in human osteosarcoma cells by regulating ROS PI3K Akt pathway

Piperlongumine induces apoptosis and synergizes with cisplatin or paclitaxel in human ovarian cancer cells

Piperlongumine Induces Apoptosis and Synergizes with Doxorubicin by Inhibiting the JAK2-STAT3 Pathway in Triple-Negative Breast Cancer

Piperlongumine Induces Apoptosis in Human Melanoma Cells Via Reactive Oxygen Species Mediated Mitochondria Disruption

Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway

Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells

Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells

Piperlongumine inhibits head and neck squamous cell carcinoma proliferation by docking to Akt

Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage

Piperlongumine inhibits neuroinflammation via regulating NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells

Piperlongumine inhibits the growth of non-small cell lung cancer cells via the miR-34b-3p TGFBR1 pathway

Piperlongumine is a novel nuclear export inhibitor with potent anticancer activity

Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells

Piperlongumine produces antidepressant-like effects in rats exposed to chronic unpredictable stress

Piperlongumine promotes death of retinoblastoma cancer cells

Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

Piperlongumine Suppresses Growth and Sensitizes Pancreatic Tumors to Gemcitabine in a Xenograft Mouse Model by Modulating the NF-kappa B Pathway

Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress

Piperlongumine, a piper alkaloid targets Ras - PI3K – Akt - mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH - DSS induced experimental colon cancer

Piperlongumine, a potent anticancer phytotherapeutic - Perspectives on contemporary status and future possibilities as an anticancer agent

Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt β-catenin pathway inactivation through ICAT

Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain

Redox-directed cancer therapeutics Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review)

Senolytic activity of piperlongumine analogues - Synthesis and biological evaluation

Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition

Synergistic effects of piperlongumine and gemcitabine against KRAS mutant lung cancer

Synthesis and biological evaluation of piperlongumine derivatives as potent anti-inflammatory agents

The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells

The Synergistic Effect of Piperlongumine and Sanguinarine on the Non-Small Lung Cancer

Senolytics

Emerging senolytic agents derived from natural products

Senolytics - Alzheimer's Drug Discovery Foundation

Senolytics in idiopathic pulmonary fibrosis - Results from a first in human, open label, pilot study

The Clinical Potential of Senolytic Drugs

To stay young, kill zombies

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