Research

As part of our ongoing commitment to transparency, we strive to give you as much comfort as possible in our product, through brining you insight into both our production quality and supporting evidence of benefits. 

There are numerous, well-documented health benefits of Purple Corn Extract, which is rich in anthocyanins.

Anthocyanins are naturally occurring pigments belonging to the flavonoid group, which is a subclass of the polyphenol family (phenolic compounds).

Phenolic compounds are natural bioactive molecules found mainly in plant tissues that have shown interesting anti-aging bioactivities, which have led to great interest in their use by the pharmaceutical industry.

There has been significant research on these compounds and topics, supporting a wide range of benefits. 

Below, please find a selection of scientific studies and research articles* for your education.  

Anti-Aging

The Case for Anthocyanin Consumption to Promote Human Health

The Benefits of Antioxidant-Rich Fruits on Skin Health

The Antioxidant Power of Purple Corn - A Research Review

Stoichiometric and kinetic studies of phenolic antioxidants from Andean purple corn and red-fleshed sweetpotato

Relationship of phenolic composition of selected purple maize genotypes with their anti-inflammatory, anti-adipogenic and anti-diabetic potential

Purple Corn phenolic compounds profile and its assessment as an agent against oxidative stress in isolated mouse organs

Purple Corn Extract as Anti-allodynic Treatment for Trigeminal Pain Role of Microglia

Polyphenols and Immune System

Influence of variety and maturity on bioactive compounds and antioxidant activity of purple waxy corn

Health Benefits of Purple Corn Phenolic Compounds

Health Benefits of Anthocyanins and Their Encapsulation for Potential Use in Food Systems - A Review

Health benefits of anthocyanins and molecular mechanisms

Effects of anthocyanins as nutraceuticals

Effects of Anthocyanins and Melatonin From Purple Waxy Corn By-Products on Collagen Production by Cultured Human Fibroblasts

Dietary Anthocyanins and Human Health

Dietary anthocyanins and health - data from FLORA and ATHENA EU projects

Dietary anthocyanin-rich plants - biochemical basis and recent progress in health benefits studies

Chemistry, Pharmacology and Health Benefits of Anthocyanins

Beneficial Effects of Anthocyanin From Natural Products on Lifestyle-Related Diseases Through Inhibition of Protease Activities

Aphrodisiac Activity of the Aqueous Crude Extract of Purple Corn

Anti-senescence compounds - A potential nutraceutical approach to healthy aging

Antimutagenic and antioxidant properties of phenolic fractions from Andean purple corn

Anthocyanins in Medicine

Anthocyanins in corn - a wealth of genes for human health

Anthocyanins and Human Health - An In Vitro Investigative Approach

Anthocyanins - Novel Antioxidants in Diseases Prevention and Human Health

Anthocyanins - Nature’s Bold, Beautiful, and Health-Promoting Colors

Anthocyanins - Natural Colorants with Health-Promoting Properties.

Anthocyanins - Multi-Target Agents for Prevention and Therapy of Chronic Diseases

Anthocyanins - From the Field to the Antioxidants in the Body

Anthocyanin Pigments - Beyond Aesthetics

Anthocyanidins and anthocyanins - colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Analysis and biological activities of anthocyanins

Gut Health

Phenolic Composition and Evaluation of the Antimicrobial Activity of Free and Bound Phenolic Fractions from a Peruvian Purple Corn Accession

Gut Microbiota, Its Role in Induction of Alzheimer's Disease Pathology, and Possible Therapeutic Interventions Special Focus on Anthocyanins

Anthocyanins as antimicrobial agents of natural plant origin

Cancer Protection

Anthocyanins from Purple Corn Ameliorated Tumor Necrosis Factor-α-Induced Inflammation and Insulin Resistance

Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis

Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways

Effects of anthocyanins on the prevention and treatment of cancer

Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers A Review of Recent Advances and Perspectives

Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula

Anthocyanins are novel AMPKα1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation

Cardiovascular Protection

Anthocyanins in cardiovascular disease

Action mechanism and cardiovascular effect of anthocyanins - a systematic review of animal and human studies

Anthocyanins - A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases

Dietary intake of anthocyanins and risk of cardiovascular disease - A systematic review and meta-analysis of prospective cohort studies

Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins

Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells

Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity

Flavanols and anthocyanins in cardiovascular health - a review of current evidence

The Effects of Natural Iridoids and Anthocyanins on Selected Parameters of Liver and Cardiovascular System Functions

Neurological Protection

Anthocyanins as a potential pharmacological agent to manage memory deficit

Anthocyanins Potentially Contribute to Defense against Alzheimer's Disease

The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the Prevention and Treatment of Brain Disorders

Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells

Oxidative stress and Alzheimer's disease - dietary polyphenols as potential therapeutic agents

Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress

Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex

Obesity & Metabolic Protection

The Influence of Supplementation of Anthocyanins on Obesity-Associated Comorbidities

Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice

Evaluation of phenolic antioxidant-linked in vitro bioactivity of Peruvian corn diversity targeting for potential management of hyperglycemia and obesity

Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects

Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice

Anthocyanins in chokeberry and purple maize attenuate diet-induced metabolic syndrome in rats

Anthocyanins in black rice, soybean and purple corn increase fecal butyric acid and prevent liver inflammation in high fat diet-induced obese mice

Diabetic Support

Anthocyanin-Rich Purple Corn Extract Inhibit Diabetes-Associated Glomerular Angiogenesis

Anthocyanins and anthocyanin-rich extracts - role in diabetes and eye function

Anthocyanins as Antidiabetic Agents - In Vitro and In Silico Approaches of Preventive and Therapeutic Effects

Anthocyanins from purple corn activate free fatty acid-receptor 1 and glucokinase enhancing in vitro insulin secretion and hepatic glucose uptake

Antidiabetic and Beta cell-protection activities of purple corn anthocyanins

Anti-diabetic effect of purple corn extract on C57BL mice

Chondroprotective effects of purple corn anthocyanins on advanced glycation end products induction through suppression of NF-κB and MAPK signaling

Preventive effect of purple corn on experimental diabetic cataract

Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation - possible renoprotective role in diabetic nephropathy

Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration

Purple corn anthocyanins retard diabetes-associated glomerulosclerosis in mesangial cells and db mice

Bioavailability & Safety

Human anthocyanin bioavailability effect of intake duration and dosing

Bioavailability of anthocyanins

A 90-day oral toxicity study of purple corn color, a natural food colorant

*We take intellectual property rights very seriously. Kindly note that neither CellFend nor any of our affiliates nor subsidiaries were involved with the funding or publication of any of these studies or articles. As such, there are no conflicts that arise. All intellectual and property rights belong to either the respective author(s) or the journal. This product is neither associated with nor endorsed by any of the respective author(s) or the journals cited above. These studies and articles are cited in their original form under the Open Access policy of the Fair Use law. If you are an author or journal representative of one of the aforementioned studies or articles, and if you believe that any of the above publications have been posted in violation of copyright, please contact us. It is not our intent to violate anyone's intellectual property rights. Therefore, we will carefully evaluate any take-down requests we receive and advise of our findings. In the event our analysis determines there exists a potential violation of intellectual property rights, we will act on it immediately.